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Sodium borohydride can be used but requires a larger excessive of reagents and lower temperatures as a result of it getting the next selectivity for carbonyl groups as opposed to imines.[97] Procedures using sodium cyanoborohydride and sodium triacetoxyborohydride (presumably created in situ from cyanoborohydride nevertheless this will not be the case because of the existence of drinking water or methanol) also cause the creation of cyanated tryptamine and beta-carboline byproducts of not known toxicity even though applying sodium borohydride in absence of acid does not.[ninety eight] Bufotenine, a plant extract, can be synthesized into copyright.[ninety nine]